Previous studies reported increased risk of acute myeloid leukaemia (AML) in individuals with inflammatory conditions. However, it is unclear whether this association is explained by preceding cytotoxic therapy or haematological diseases.
eBook Title: Autoimmune Diseases, Infections, Use of Antibiotics and the Risk of Acute Myeloid Leukaemia: a National Population‐based Case‐control Study
Author:
Published on 2018 by
Previous studies reported increased risk of acute myeloid leukaemia (AML) in individuals with inflammatory conditions. However, it is unclear whether this association is explained by preceding cytotoxic therapy or haematological diseases. We conducted a nationwide case‐control study that included 3053 AML patients, diagnosed in Denmark between 2000 and 2013, and 30 530 sex‐ and age‐matched population controls. We retrieved information on autoimmune disease, infections, and use of antibiotics and computed odds ratios for AML (conditional logistic regression). Results were stratified by AML type, sex, and age. Autoimmune diseases were associated with an overall increased risk of AML {odds ratio [OR] 1·3 [95% confidence interval (CI) = 1·1–1·5]}. However, the risk was confined to patients with previous haematological disease or cytotoxic therapy exposure [secondary/therapy‐related AML (sAML/tAML0) OR 2·0 (95% CI = 1·6–2·6)] and not de novo AML [OR 1·1 (95% CI = 0·9–1·3)]. Similarly, any prior infection requiring hospitalization was associated with a higher risk of AML [OR 1·3 (95% CI = 1·1–1·4)]. Again, this association was evident for sAML/tAML [OR 1·8 (95% CI = 1·5–2·2)], and not de novo AML [OR 1·1 (95% CI = 1·0–1·2)]. In conclusion, autoimmune diseases and infections were associated with an increased AML risk only in subjects with prior haematological disease and/or cytotoxic treatment. These observations suggest, that inflammation plays – if any – a minor role for the development of de novo AML.
From the most popular Autoimmune Disease Books, Autoimmune Diseases, Infections, Use of Antibiotics and the Risk of Acute Myeloid Leukaemia: a National Population‐based Case‐control Study is the one of great book to have. You can download ebook from:
entitled: Autoimmune Diseases, Infections, Use of Antibiotics and the Risk of Acute Myeloid Leukaemia: a National Population‐based Case‐control Study here. There are so many ebooks about Autoimmune Diseases, Infections, Use of Antibiotics and the Risk of Acute Myeloid Leukaemia: a National Population‐based Case‐control Study that are available to download. Thinking of having free ebooks by Download Autoimmune Diseases, Infections, Use of Antibiotics and the Risk of Acute Myeloid Leukaemia: a National Population‐based Case‐control Study ebook rather than buy? You are in the right place. Download ebook Autoimmune Diseases, Infections, Use of Antibiotics and the Risk of Acute Myeloid Leukaemia: a National Population‐based Case‐control Study by: .
- Book was ranked at 36 by Google Books for Autoimmune Diseases, Infections, Use of Antibiotics and the Risk of Acute Myeloid Leukaemia: a National Population‐based Case‐control Study
- Autoimmune Diseases, Infections, Use of Antibiotics and the Risk of Acute Myeloid Leukaemia: a National Population‐based Case‐control Study published by since 2018 with ISBNs. The book ISBN 13 Code is and ISBN 10 Code is
- Reading Mode in Text Status is false and Reading Mode in Image Status is false
- The book has " Pages" is Printed at BOOK under Category
- Rated by Raters and have average rate at ""
- eBook Maturity (Adult Book) status is NOT_MATURE
- eBook written in en
- Book Preview Address: http://books.google.com/books?id=WEsDvgEACAAJ&dq=Autoimmune+Disease&hl=&cd=275&source=gbs_api
Book Preview
- Server 1: FAST DOWNLOAD
- Server 2: SECURE DOWNLOAD
- Server 3: FAST DOWNLOAD