Stohl W (ed): B Cell Trophic Factors and B Cell Antagonism in \u003cb\u003eAutoimmune\u003c/b\u003e \u003cbr\u003e\n\u003cb\u003eDisease\u003c/b\u003e. Curr Dir Autoimmun. Basel, Karger, 2005, vol 8, pp 25–54 Regulatory \u003cbr\u003e\nRoles for Cytokine- Producing B Cells in Infection and \u003cb\u003eAutoimmune Disease\u003c/b\u003e \u003cbr\u003e\nFrances ...
eBook Title: B Cell Trophic Factors and B Cell Antagonism in Autoimmune Disease
Author:William Stohl
Published on 2005-01-01 by Karger Medical and Scientific Publishers
The understanding of B cell biology has increased and expanded enormously in the last three decades. It is now known that B cells, in addition to just differentiating into antibody-secreting cells, serve many other vital functions. For example, their roles as antigen-presenting cells and cytokine-producing cells as well as effector cells and regulatory cells are well appreciated now. Indeed, the pathologic role of B cells in many autoimmune disorders may be largely autoantibody-independent. Today, the B cell is of considerable interest not only to immunologists but also to mainstream clinicians and scientists. The current volume covers the latest information on the functions of B cells in normal and disease states, and their therapeutic antagonism. Chapters cover cutting-edge topics from the basic to the clinical, including B cells in infection and autoimmunity, CD19-CD21 signal transduction complex, marginal zone B cell physiology and disease, B cell growth and differentiation, their role in rheumatoid arthritis, SLE treatment, the BAFF/APRIL system and B lymphocyte malignancies. This book is recommended reading for cellular and molecular immunologists as well as for rheumatologists, hematologists and clinical immunologists, and all those interested in human diseases in which B cells play an important contributory role.
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William Stohl
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